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Troponin-T Levels: New A-fib Risk Factor?

A study published last month found that serial measures of high sensitivity cardiac troponin-T (hs-cTnT) levels may be used to predict incident atrial fibrillation (AF) independent of traditional risk factors. The study suggests that circulating troponin levels caused by either myocyte damage or protein turnover predispose older adults to AF and that it is a important part of the cardiac remodeling process. Higher baseline levels of Troponin-T were associated with a higher likelihood of developing incident AF. There are currently no interventions available for elevated troponin-T levels as a risk factor for developing AF but this association is important to advance knowledge regarding the mechanisms that lead to AF.

I believe that this is an interesting study because usually sometimes people may not even recognize symptoms of A-fib and the diagnosis may be delayed if people to not seek treatment, which could potentially lead to poorer outcomes. Although there are currently no interventions for elevated troponin-T levels as predictors of A-fib, the idea of an additional risk factor for A-fib could at the very least make providers more aware of the problem so that they could monitor patients closely and educate them of the signs and symptoms of A-fib if it does occur. Hopefully in the future we will be able to use this biomarker to “catch” A-fib and implement interventions before it even happens.

 

Hussein A, Bartz T, Gottdiener J, et al. Serial measures of cardiac troponin-T levels by a highly sensitive assay and incident atrial fibrillation in a prospective cohort of ambulatory older adults. Heart Rhythm 2015; DOI:10.1016/j.hrthm.2015.01.020

Transcatheter Aortic Valve Replacement (TAVR)

I am fascinated with how technology has advanced and how it works, especially to fix cardiovascular diseases. I would like to share with everyone the coolest procedure that fixes aortic stenosis, called transcatheter aortic valve replacement, best known as TAVR. This procedure is for patients who suffer from severe aortic stenosis and whose advanced age puts them at high risk for death if they were to have open-heart surgery. The University of Iowa Heart and Vascular Center is one of a select group of centers across the nation, and the first in Iowa to offer this procedure to those qualified candidates (University of Iowa Hospitals and Clinics, 2015). In 2011, this center was the first in the nation to receive certification for its cardiac valve program from The Joint Commission (University of Iowa Hospitals and Clinics, 2015). It is important to note that this procedure is minimally invasive for the repair and replacement of the aortic valve. This procedure can be performed through two distinct sites, either from the patient’s thigh through the femoral artery or through a small incision on the lower left side of the patient’s chest. Sometimes the elderly have disease of the leg blood vessels; hence, the chest can be an alternative site (University of Iowa Hospitals and Clinics, 2015).

 

Basically, with this procedure, the damaged aortic valve is replaced with a prosthetic valve. This new technology uses a catheter inserted through a small incision in a patient’s thigh that travels though blood vessels and can be used to replace a person’s failing heart valve in the aortic artery. This procedure involves a team of interventional cardiologists, cardiac surgeons, and imaging specialists of the heart (University of Iowa Hospitals and Clinics, 2015). The recovery of this procedure is faster as opposed to open-heart surgery and it has proven to be a successful procedure. As we know, the blood passes through the aortic valve and then into our body where it perfusses our tissues and organs. If the valve is stenotic, then small amounts of blood can pass through this valve and symptoms develop such as shortness of breath and one can easily become tired. In the story of a 90-year-old woman, she would complain of being tired on a day-to-day basis and that led her to visit her doctor (University of Iowa Hospitals and Clinics, 2015). She then was diagnosed with aortic stenosis and the doctor recommended for this procedure. She agreed to undergo TARV and she admits it was the best decision made for improving her health. After four days, she was allowed to go home and she says she had no pain at all after the procedure (University of Iowa Hospitals and Clinics, 2015). She recommends this procedure for those who need it and overall she is doing well. Patients who don’t get treated for aortic stenosis can develop heart failure or cardiac arrest, and most importantly can die within a year of this problem (University of Iowa Hospitals and Clinics, 2015). By the way, check out the article below and you can watch the animated video of this procedure, which is amazing!

 

Reference:

University of Iowa Hospitals and Clinics. (2015). Transcatheter aortic valve replacement. Retrieved    from        http://www.uihealthcare.org/2column.aspx?id=227967

University of Iowa Hospitals and Clinics. (2015).

Alma’s story: New lease on life.       Retrieved from    http://www.uihealthcare.org/2column.aspx?id=230803

 

 

Basic ECG from a Mobile Device: AliveCor

AliveCor is a mobile ECG device and app that attaches to a smartphone and interprets the heart’s electrical activity equivalent to a basic 1-lead ECG. While it does not replace the standard 12-lead ECG, it does allow patients to monitor their basic heart rhythms as they go about their daily lives. AliveCor is FDA-approved to detect Atrial Fibrillation and a study published in JAMA has shown it to be able to detect wide complex tachycardia. When used to its full potential, the device and app can track an individual’s heart rhythms as they correspond to daily life. The individual records their ECG tracing then can enter details about their activity, diet, medications, etc. All of this information is stored for later reference and comparison or it can be sent to the patient’s cardiologist by email for immediate review. This device enables cardiologists to gather more comprehensive data about the activity of their patients’ hearts instead of having to rely on office visit ECG monitoring that may not be an accurate reflection of the patients’ varying conditions. As we truly live in a mobile world with increasing use and dependence on smartphones, it is exciting to see healthcare providers begin embracing the use of  smartphones in their practice to improve the health of their patients.

References:

http://www.alivecor.com/research

Waks, J. W., Fein, A. S., & Das, S. (2015). Wide complex tachycardia recorded with a smartphone cardiac rhythm monitor. JAMA Internal Medicine.

doi:10.1001/jamainternmed.2014.7586.

Retrieved from http://archinte.jamanetwork.com/article.aspx?articleid=2091739#

Customizing cardiac implants

While conducting research for this week’s assignment regarding the newest cardiovascular technology, I came across this great article discussing heart implants and them being “tailor-made” (Bourzac, 2014). Current cardiac implants, such as pacemakers and defibrillators, are not custom made as they are basically “one size fits all” (Bourzac, 2014, para. 1). The article discusses researchers who have created a personalized heart sensor using a 3-D printer and their utilization of a stretchy material to create a perfect fit that would increase the level of monitoring and treatment of cardiac implants (Bourzac, 2014). The stretchy material would increase the effectiveness of oxygen monitoring, strain gauges, electrodes, and temperature monitoring as it would be customized to the person’s heart (Bourzac, 2014). An interesting concept presented in the article is the idea of sensors being placed on cardiac implants that could measure acidic conditions (Bourzac, 2014). In addition, light sensors could be placed on this stretchy material and would “provide information about heart-tissue health by identifying areas with poorly oxygenated blood, which is less transparent to light,” and could ultimately identify the occurrence of a myocardial infarction (Bourzac, 2014, para. 5). I think any time we are able to customize a treatment, we are able to better serve our patients and this concept of 3-D printing will most certainly contribute to higher quality patient care.

References:

Bourzac, K. (2014). Heart Implants, 3-D- – Printed to Order. Retrieved from:http://www.technologyreview.com/news/525221/heart-implants-3-d-printed-to-  order/

Cardiovascular Treatment: Stem Cell Therapy for Heart Disease

We have all learned about stem cell therapy in the context of procedures such as bone marrow transplantation for cancer patients. Recently, there has also been significant research regarding testing the use of stem cells in the treatment of heart disease and the improvement of complications from acute myocardial infarction (AMI), heart failure, and cardiomyopathies. With AMI, percutaneous coronary intervention (PCI) has become standard treatment, and it is successful in reducing mortality (Puliafico, Penn, & Silver, 2013). This reduction in mortality however is associated with people living with the long-term complications of AMI, such as heart failure, in which half will die within five years of diagnosis (Puliafico, Penn, & Silver, 2013).

Then came the discovery of cardiac stem cells (Puliafico, Penn, & Silver, 2013). These stem cells are activated in the event of an AMI to attempt to repair damaged myocardium. It was then found that non-cardiac stem cells, such as those from bone marrow or adipose, can transdifferentiate into cardiomyocytes to help repair damaged heart tissue. There have been a multitude of different types of stem cells tested, along with different routes of infusing or injecting them into heart or vessel tissue. Research has shown that the introduction of stem cells after an AMI can improve ventricular ejection fraction (EF), volumes, wall motion, and infarct size. In heart failure patients, stem cells have also improved ventricular function through EF, improved functional class, reduced infarct size, decreased mortality, and acceptable safety outcomes (Puliafico, Penn, & Silver, 2013).

I think that this topic is fascinating because it has so much potential to save lives and improve outcomes for those with heart disease. Heart disease is the number one leading cause of death in the United States, and that will most likely not be changing anytime soon (Puliafico, Penn, & Silver, 2013). The research that is done now regarding stem cells can not only lead to improved outcomes for heart disease patients, but it can lead to future research for so many other conditions. While results presented in the article showed that improved outcomes were not consistent across a number of studies, it could be due to the multitude of different stem cells and administration methods possible. More research will be needed because cardiovascular stem cell therapy is still in its infancy. It is exciting to see where this research could potentially lead to though.

Reference:

Puliafico, S.B., Penn, M.S., & Silver, K.H. (2013). Stem cell therapy for heart disease. Journal of General Internal Medicine, 28(10), 1353-1363.

Image: http://www3.imperial.ac.uk/newseventsimages?p_image_type=mainnews2012&p_image_id=23503

Technological Advancements

Due to the advancements of technology, Jenna and I thought it would be beneficial to research current cardiac applications available on our smart phones from the patient’s perspective; HeartDecide was quickly discovered. This free application, available for all Apple products, introduced an all-encompassing cardiovascular easy-to-use tool for patients to understand their respective cardiac anatomy, conditions, and procedures. Although this application was released in 2012 by Orca Health, Inc. at Harvard University, it is continuously updating its information with a copyright date until 2015. Once downloaded, the user has the option of entering the application as a doctor, nurse, or patient. We reviewed the information as if we were a patient, browsing to find a specific medical condition. For instance, we searched “heart attack” via the “conditions” tab and found a simple video lasting 1 minute and 32 seconds. In addition, there are written materials provided after the video by swiping the screen to the left. Here we found a frequently asked question and answer section detailing “what is a heart attack,” “what causes a heart attack,” “what are the symptoms,” and “how is a heart attack treated.” Furthermore, there are numerous conditions available to search such as angina, atherosclerosis, atrial fibrillation, sudden cardiac death, heart failure, and many more. We both believe this to be a great informational tool for patients in order to understand more about their clinical condition.

HeartDecide can be used as a supplemental tool to the education provided by the cardiologist. Often, when patients are newly diagnosed with a cardiac condition or a trauma occurs, they are not able to fully comprehend and/or process the education provided by the clinicians. They can learn great detail about their condition(s) on their own time once they are psychologically prepared to do so. Therefore, we highly recommend this application to all clients with a cardiac condition <3

Cardiovascular Technological Advancement

Due to the advancements of technology, Allie and I thought it would be beneficial to research current cardiac applications available on our smart phones from the patient’s perspective; HeartDecide was quickly discovered. This free application, available for all Apple products, introduced an all-encompassing cardiovascular easy-to-use tool for patients to understand their respective cardiac anatomy, conditions, and procedures. Although this application was released in 2012 by Orca Health, Inc. at Harvard University, it is continuously updating its information with a copyright date until 2015. Once downloaded, the user has the option of entering the application as a doctor, nurse, or patient. We reviewed the information as if we were a patient, browsing to find a specific medical condition. For instance, we searched “heart attack” via the “conditions” tab and found a simple video lasting 1 minute and 32 seconds. In addition, there are written materials provided after the video by swiping the screen to the left. Here we found a frequently asked question and answer section detailing “what is a heart attack,” “what causes a heart attack,” “what are the symptoms,” and “how is a heart attack treated.” Furthermore, there are numerous conditions available to search such as angina, atherosclerosis, atrial fibrillation, sudden cardiac death, heart failure, and many more. We both believe this to be a great informational tool for patients in order to understand more about their clinical condition.

HeartDecide can be used as a supplemental tool to the education provided by the cardiologist. Often, when patients are newly diagnosed with a cardiac condition or a trauma occurs, they are not able to fully comprehend and/or process the education provided by the clinicians. They can learn great detail about their condition(s) on their own time once they are psychologically prepared to do so. Therefore, we highly recommend this application to all clients with a cardiac condition <3

The use of mobile technology to enhance CVD screening

mobile-healthcare-app-271x300Recognizing those at risk for CVD is a primary prevention. I found a study that compared a the use of a non-laboratory, paper-based CVD risk assessment chart tool to a mobile phone CVD risk assessment application. The goal was to compare the time it would take to train community health workers, the duration of screening. The paper-based tool was created to avoid laboratory costs; the tool substitutes the body-mass-index for blood lipid level to calculate the CVD risks. This makes screening easier and the best part is that it is cost effective. The development of the mobile device was so it could automatically calculate CVD risks scores with less room for error due to manual calculations and so it could be directly carried into communities. This is an excellent resource that is being used in low-resource settings. The mobile device is also better than the paper-based tool because it can be used by those with a lower set of skills.
The use of the mobile device had some pros and cons. One positive outcome was that it took less time to train personnel in the use of the mobile device compared with the paper-based tool. The mobile device was faster at yielding results. Many of the health care workers felt that there was less room for error because they did not have to manually do calculations. Some cons were that in previous times the visual chart was being used to explain to clients what their results meant. Many also felt that having the detailed chart gave them a better understanding of calculating the risk but with the phone everything was basically done for them.
I really liked this article because it talked about how technology is being used in lower income settings were detecting those at risk for CVD is a high priority. This mobile device it taken into communities, which in my opinion is the way to go because some clients have difficulties with transportation. The device can then calculate the client’s CVD risk and they are then educated or referred to a health care provider. Having a tool that requires little training, has little room for error, and yields quicker results will enhance CVD screening. This is important because the more people that are being screened the more people we can prevent from developing CVD. A con that I would also have trouble with is the fact that the machine is doing everything and when compared to the paper-tool where the calculations were being done and understood by the workers I am not sure how well the workers would understand what the results actually mean when using this technology. The article mentioned that this is being done in South Africa but this would be nice to have in our communities where many are not screened for CVD as a result of more than one obstacle.

References

Surka, S., Edirippulige, S., Steyn, K., Gaziano, T., Puoane, T., & Levitt, N. (2014). Evaluating the use of mobile phone technology to enhance cardiovascular disease screening by community health workers. International Journal Of Medical Informatics, 83(9), 648-654. doi:10.1016/j.ijmedinf.2014.06.008

Implantable Wireless Device that Measures Pulmonary Artery Pressure in Patients with HF

 

Heart Failure is a   common condition  with more than 5 million Americans affected by it. In order to treat heart failure lifestyle modifications and a medication regimen is followed.  Currently St Jude Medical released their new product called the Cardio MEMS HF System. It is the first FDA-approved HF monitoring device that has been proven to reduce hospital admissions and improve quality of life in NYHA class III HF patients who have been hospitalized in the previous 12 months. Wow! But you may ask your self how does this really work? Well a senor is placed in the pulmonary artery, it reads the  pressures, and sends the reading  automatically to your providers desktop where he can view the reading through a secure website. The sensor itself is powered by radio frequency energy and is implanted in the pulmonary artery via a a catheter. The procedure is non-invasive and the sensor lasts for the lifetime of the patient. No battery is required, and the sensor sends out information to an electronic transmitter. In order to initiate readings the patient lies down on a special pillow and the electronic unit guides the patient on how to initiate a reading. Once the reading is complete, which only takes a few minutes, the readings are transmitted wirelessly  to a secure website.  The physician  reviews the readings and makes any necessary adjustments to the patients treatment. Pulmonary artery pressure is reflective of the patients heart condition. The sensor allows daily monitoring at home without the inconvenience of having to visit the doctors office. It is also easy and fast. Most importantly it can prevent future hospitalizations through early detection of changes pulmonary artery pressure.

CardioMEMS™ HF System

Week 4: Cardiovascular

StJudeMedical_CardioMEMS_monitoring_sensorThe CardioMEMS HF System is a small implantable device for patients with heart failure, hypertension, peripheral neuropathy and other additional cardiovascular disorders that eventually result in heart failure. This device was created with the purpose of better managing heart failure in patients from their homes. The CardioMEMS HF is a sensor/ monitor device that is smaller than a dime and does not require any batteries. The device is placed through the distal pulmonary artery. Once home, the patient’s heart rate and artery pressures will be monitored daily by the CardioMEMS HF; on the other side, at a health facility, a physician or nurse will review the information. If there is an abnormality noted then a change to the patient’s medical therapy will be made. Through the use of CardioMEMS HF, the researchers hope to decrease hospitalizations by not having the patients come in to the hospital until they are experiencing severe symptoms from HF. In other words, the aim is to reduce hospitalizations through early interventions.

In regards to my opinion regarding CardioMEMS HF, I think it’s a great idea in that it could possibly decrease hospitalizations through early intervention; however, I find it a bit difficult on how the healthcare workers are going to get in contact with the patient to change the medical regimen when they identify an abnormality. Furthermore, in the case when the patient does have the CardioMEMS HF is implanted I believe that the patient should use standard self-monitoring in conjunction; this includes: self-monitoring of blood pressures.

Below is the link regarding CardioMEMS HF.

http://www.ucsf.edu/news/2014/10/119411/new-miniature-device-monitors-heart-failure-patients-remotely