Renal GU Drug Review! Prinivil
Lisinopril (Prinivil )
Who?:
- Patients with hypertension
- Patients with heart failure
- Patients with acute MI
What?:
- Ace Inhibitors
- Inhibits angiotensin converting enzyme from converting angiotensin I to angiotensin II. It also prevents the degradation of bradykinin and other vasodilatory prostaglandins. Also increases plasma renin levels and decreases aldosterone levels. Net result is systemic vasodilation.
When?:
- Once daily
Where?:
- Chronic home med
Why?:
- Management of patients with hypertension (high blood pressure); for those who had an MI; or to manage heart failure.
- Vasodilator
How?:
- Hypertension: Adults (PO)= 10mg once daily, can be increased to 20-40 mg/day
- Renal: Adults (PO)= Initiate at 2.5-5mg daily; may be slowly titrated up to 40 mg/day.
- Heart failure: Adults (PO)= 5 mg once daily, may be titrated every 2 weeks up to 40 mg/day. Initiate at 2.5 mg once daily for patients with hyponatremia.
- MI: Adults (PO)= 5 mg once daily for 2 days, then 10 mg daily.
- Safety: Avoid salt substitutes; hypotension; hyperkalemia risk; notify health care professional if rash, mouth sores, sore throat, fever, swelling of hands or feet, irregular heart beat, chest pain, dry cough, hoarseness.; fetal harm; angioedema (facial swelling and dyspnea).
